Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9-Reference-Cited by-同舟云学术

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

Published:2018-09-25 Issue:549 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Luttrell Louis M.¹²³^ORCID,Wang Jialu⁴,Plouffe Bianca⁵^ORCID,Smith Jeffrey S.⁴⁶^ORCID,Yamani Lama⁷,Kaur Suneet⁴,Jean-Charles Pierre-Yves⁴,Gauthier Christophe⁸,Lee Mi-Hye¹,Pani Biswaranjan⁴^ORCID,Kim Jihee⁴,Ahn Seungkirl⁴,Rajagopal Sudarshan⁴⁶^ORCID,Reiter Eric⁸,Bouvier Michel⁵^ORCID,Shenoy Sudha K.⁴⁹^ORCID,Laporte Stéphane A.⁷^ORCID,Rockman Howard A.⁴⁹¹⁰,Lefkowitz Robert J.⁴⁶¹¹^ORCID

Affiliation:

1. Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

2. Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

3. Research Service of the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29401, USA.

4. Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

5. Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec H3C IJ4, Canada.

6. Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.

7. Department of Medicine, Research Institute of the McGill University Health Center, McGill University, Montreal, Quebec H4A 3J1, Canada.

8. Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, CNRS, Université de Tours, 37380 Nouzilly, France.

9. Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

10. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.

11. Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

β-Arrestin proteins fine-tune different GPCR-stimulated pathways that converge on ERK1/2 activation.

Funder

National Heart, Lung, and Blood Institute

National Institute of General Medical Sciences

National Institute of Diabetes and Digestive and Kidney Diseases

Canadian Institutes of Health Foundation Grant

Canadian Institutes of Health Research

French National Research Agency Investissements d’avenir program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference111 articles.

1. Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

2. cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

3. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

4. Dancing with Different Partners: Protein Kinase A Phosphorylation of Seven Membrane-Spanning Receptors Regulates Their G Protein-Coupling Specificity

5. Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

Cited by 176 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Phosphorylation patterns in the AT1R C-terminal tail specify distinct downstream signaling pathways;Science Signaling;2024-08-13

2. Functional consequences of spatial, temporal and ligand bias of G protein-coupled receptors;Nature Reviews Nephrology;2024-07-22

3. Aniquinazoline B, a Fungal Natural Product, Activates the μ‐Opioid Receptor;ChemMedChem;2024-07-15

4. Role of the V2R–βarrestin–Gβγ complex in promoting G protein translocation to endosomes;Communications Biology;2024-07-07

5. GPCR-dependent and -independent arrestin signaling;Trends in Pharmacological Sciences;2024-07