The neuropilin 2 isoform NRP2b uniquely supports TGFβ-mediated progression in lung cancer-Reference-Cited by-同舟云学术

The neuropilin 2 isoform NRP2b uniquely supports TGFβ-mediated progression in lung cancer

Published:2017-01-17 Issue:462 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Gemmill Robert M.¹,Nasarre Patrick¹,Nair-Menon Joyce¹,Cappuzzo Federico²,Landi Lorenza³,D’Incecco Armida³,Uramoto Hidetaka⁴,Yoshida Takeshi⁵,Haura Eric B.⁵,Armeson Kent⁶,Drabkin Harry A.¹

Affiliation:

1. Division of Hematology/Oncology, Department of Medicine, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.

2. Azienda Unità Sanitaria Locale della Romagna, Ravenna 48100, Italy.

3. Medical Oncology Department, Istituto Toscano Tumori, Ospedale Civile di Livorno, Viale Alfieri 36, Leghorn 57100, Italy.

4. Division of Thoracic Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada 920-0293, Japan.

5. Department of Thoracic Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA.

6. Department of Public Health Sciences, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.

Abstract

NRP2b connects oncogenic TGFβ to enhanced responsiveness to the promigratory growth factor HGF in non–small cell lung cancer cells.

Funder

National Cancer Institute

Veterans Administration

Hollings Cancer Center, MUSC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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