Unconventional Roles of the NADPH Oxidase: Signaling, Ion Homeostasis, and Cell Death-Reference-Cited by-同舟云学术

Unconventional Roles of the NADPH Oxidase: Signaling, Ion Homeostasis, and Cell Death

Published:2007-03-27 Issue:379 Volume:2007 Page:
ISSN:1525-8882
Container-title:Science's STKE
language:en
Short-container-title:Sci. STKE

Author:

Steinberg Benjamin E.¹,Grinstein Sergio¹

Affiliation:

1. Program in Cell Biology, Hospital for Sick Children, Toronto, Canada M5G 1X8 and Institute of Medical Science, University of Toronto, Ontario, Canada M5S 1A8.

Abstract

Although the central role of the phagocytic NADPH oxidase in mediating bacterial killing has long been appreciated, this sophisticated enzyme complex serves various other important functions. This Perspective focuses on these underappreciated roles of phagocytic NADPH oxidase, highlighting recent work implicating reactive oxygen species in triggering an unconventional form of cell death.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference34 articles.

1. Neutrophils from p40phox−/− mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing

2. The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcγIIA receptor–induced phagocytosis

3. NADPH oxidase

4. Cytoplasmic pH regulation in phorbol ester-activated human neutrophils

5. Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis

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