Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia

Author:

Auvinen Juha12ORCID,Tapio Joona34ORCID,Karhunen Ville156ORCID,Kettunen Johannes1378,Serpi Raisa34ORCID,Dimova Elitsa Y.34ORCID,Gill Dipender59ORCID,Soininen Pasi78,Tammelin Tuija10ORCID,Mykkänen Juha1112,Puukka Katri13,Kähönen Mika14,Raitoharju Emma15ORCID,Lehtimäki Terho15ORCID,Ala-Korpela Mika1378ORCID,Raitakari Olli T.111216,Keinänen-Kiukaanniemi Sirkka117ORCID,Järvelin Marjo-Riitta13171819ORCID,Koivunen Peppi34ORCID

Affiliation:

1. Faculty of Medicine, Center for Life Course Health Research, University of Oulu, 90014 Oulu, Finland.

2. Medical Research Center, Oulu University Hospital and University of Oulu, 90220 Oulu, Finland.

3. Biocenter Oulu, 90014 Oulu, Finland.

4. Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, 90014 Oulu, Finland.

5. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, W2 1PG London, UK.

6. Research Unit of Mathematical Sciences, University of Oulu, 90014 Oulu, Finland

7. Computational Medicine, Faculty of Medicine, University of Oulu, 90014 Oulu, Finland.

8. NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, 70210 Kuopio, Finland.

9. Clinical Pharmacology and Therapeutics Section, Institute of Medical and Biomedical Education and Institute for Infection and Immunity, St George’s, University of London, London, UK.

10. LIKES Research Center for Physical Activity and Health, 40700 Jyväskylä, Finland.

11. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland.

12. Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.

13. NordLab Oulu, Medical Research Center Oulu, Oulu University Hospital and Department of Clinical Chemistry, University of Oulu, 90014 Oulu, Finland.

14. Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

15. Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center - Tampere, Tampere University, Tampere, Finland.

16. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, 20520 Turku, Finland.

17. Unit of Primary Care, Oulu University Hospital, 90220 Oulu, Finland.

18. Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.

19. Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, Middlesex UB8 3PH, UK.

Abstract

Low-end normal hemoglobin levels, which carry less oxygen, are associated with lower body weight and healthier metabolism.

Funder

Horizon 2020 Framework Programme

Suomen Akatemia

British Heart Foundation

Tays

FUNDING

European Regional Development Fund

UK Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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