Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer

Author:

Singhal Hari1,Greene Marianne E.1ORCID,Tarulli Gerard2,Zarnke Allison L.1ORCID,Bourgo Ryan J.1,Laine Muriel1,Chang Ya-Fang1,Ma Shihong3,Dembo Anna G.1ORCID,Raj Ganesh V.3,Hickey Theresa E.2ORCID,Tilley Wayne D.2,Greene Geoffrey L.1

Affiliation:

1. Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA.

2. Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, University of Adelaide, Adelaide, South Australia 5005, Australia.

3. Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75080, USA.

Abstract

Individual and concerted actions of ER and PR highlight the prognostic and therapeutic value of PR in ER + /PR + breast cancers.

Funder

Virginia and D.K. Ludwig Fund for Cancer Research

National Health and Medical Research Council of Australia

National Breast Cancer Foundation

Cancer Prevention and Research Institute of Texas

U.S. Department of Defense

Department of Defense Breast Cancer Research Program

Susan G. Komen Postdoctoral Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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