Liquid biopsy and therapeutic response: Circulating tumor cell cultures for evaluation of anticancer treatment

Author:

Khoo Bee Luan1,Grenci Gianluca2ORCID,Jing Tengyang13,Lim Ying Bena3,Lee Soo Chin45,Thiery Jean Paul6ORCID,Han Jongyoon17,Lim Chwee Teck1238

Affiliation:

1. BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore 138602, Singapore.

2. Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.

3. Department of Biomedical Engineering, National University of Singapore, 7 Engineering Drive 1, Singapore 117574, Singapore.

4. Department of Hematology-Oncology, National University Cancer Institute, National University Hospital, Singapore 119074, Singapore.

5. Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.

6. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.

7. Department of Electrical Engineering and Computer Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

8. Department of Mechanical Engineering, National University of Singapore, Singapore 117575, Singapore.

Abstract

A patient-derived CTC culture assay for anticancer drug evaluation to guide therapy for personalized treatment.

Funder

Mechanobiology Institute

Singapore-MIT Alliance for Research and Technology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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