Actin kinetics shapes cortical network structure and mechanics

Author:

Fritzsche Marco1,Erlenkämper Christoph23ORCID,Moeendarbary Emad45ORCID,Charras Guillaume6,Kruse Karsten2ORCID

Affiliation:

1. MRC Human Immunology Unit, Weatherall Institute for Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.

2. Theoretische Physik, Universität des Saarlandes, 66041 Saarbrücken, Germany.

3. Institut Curie, 26 Rue d’Ulm, 75248 Paris Cedex 05, France.

4. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

5. Department of Mechanical Engineering, University College London, London WC1E 7JE, UK.

6. London Centre for Nanotechnology, Institute for the Physics of Living Systems, and Department of Cell and Developmental Biology, University College London, London WC1H 0AH, UK.

Abstract

Cells adjust their macroscopic mechanical properties by tuning the actin protomer concentration and activity of actin nucleators.

Funder

Human Frontier Science Program

Wellcome Trust

Deutsche Forschungsgemeinschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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