CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction-Reference-Cited by-同舟云学术

CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction

Published:2017-09 Issue:9 Volume:3 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Alvarez Frances J. D.¹²^ORCID,He Shaoda³,Perilla Juan R.⁴^ORCID,Jang Sooin²⁵⁶^ORCID,Schulten Klaus⁴,Engelman Alan N.²⁵⁶,Scheres Sjors H. W.³,Zhang Peijun¹²⁷⁸^ORCID

Affiliation:

1. Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.

2. Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.

3. MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

4. Department of Physics and Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

5. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

6. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

7. Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Headington, Oxford OX3 7BN, UK.

8. Electron Bio-Imaging Centre, Diamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, UK.

Abstract

CryoEM structure of MxB tubes at 4.6 Å resolution reveals novel interfaces responsible for assembly and anti–HIV-1 activity.

Funder

National Science Foundation

National Institutes of Health

MRC

National Institute of General Medical Sciences

Wellcome Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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4. cDNA structures and regulation of two interferon-induced human Mx proteins;Aebi M.;Mol. Cell. Biol.,1989

5. Human MxB protein, an interferon-α-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope;Melén K.;J. Biol. Chem.,1996

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