Ligand binding to a G protein–coupled receptor captured in a mass spectrometer-Reference-Cited by-同舟云学术

Ligand binding to a G protein–coupled receptor captured in a mass spectrometer

Published:2017-06-02 Issue:6 Volume:3 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Yen Hsin-Yung¹,Hopper Jonathan T. S.²,Liko Idlir¹²,Allison Timothy M.¹,Zhu Ya³,Wang Dejian³⁴,Stegmann Monika⁵,Mohammed Shabaz⁵^ORCID,Wu Beili³⁴,Robinson Carol V.¹

Affiliation:

1. Chemistry Research Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QZ, UK.

2. OMass Technologies Ltd., Centre for Innovation and Enterprise, Begbroke Science Park, Woodstock Road, Oxford OX5 1PF, UK.

3. CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai 201203, China.

4. School of Life Science and Technology, ShanghaiTech University, 99 Haike Road, Pudong, Shanghai 201203, China.

5. Departments of Chemistry and Biochemistry, University of Oxford, Oxford OX1 3QU, UK.

Abstract

Drug binding to the P2Y 1 receptor prevents phosphorylation and competes with an endogenous ligand.

Funder

Wellcome Trust

European Research Council

Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary