Mechanisms of murine cerebral malaria: Multimodal imaging of altered cerebral metabolism and protein oxidation at hemorrhage sites

Author:

Hackett Mark J.1,Aitken Jade B.1ORCID,El-Assaad Fatima2,McQuillan James A.3,Carter Elizabeth A.1ORCID,Ball Helen J.3,Tobin Mark J.4ORCID,Paterson David4ORCID,de Jonge Martin D.4ORCID,Siegele Rainer5ORCID,Cohen David D.5ORCID,Vogt Stefan6,Grau Georges E.2,Hunt Nicholas H.3,Lay Peter A.1ORCID

Affiliation:

1. School of Chemistry and Vibrational Spectroscopy Core Facility, The University of Sydney, Sydney, New South Wales 2006, Australia.

2. Vascular Immunology Unit, Bosch Institute and School of Medical Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia.

3. Molecular Immunopathology Unit, Bosch Institute and School of Medical Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia.

4. Australian Synchrotron, 800 Blackburn Road, Clayton, Victoria 3168, Australia.

5. Institute for Environmental Research, Australian Nuclear Science and Technology Organisation, Lucas Heights, New South Wales 2234, Australia.

6. Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439, USA.

Abstract

Multimodal spectroscopic imaging resolved controversies on biochemical changes associated with cerebral malaria pathology.

Funder

University of Sydney

Department of Industry, Innovation, Science, Research and Tertiary Education, Australian Government

Australian Institute of Nuclear Science and Engineering

Australian Research Council

National Health and Medical Research Council

Australian Synchrotron

U.S. Department of Energy

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference94 articles.

1. WHO World Malaria Report 2014 (World Health Organization Geneva 2014).

2. Residual neurologic sequelae after childhood cerebral malaria;van Hensbroek M. B.;J. Pediatr.,1997

3. Clinical features and pathogenesis of severe malaria;Mackintosh C. L.;Trends Parasitol.,2004

4. Cerebral malaria—A neurovascular pathology with many riddles still to be solved;Coltel N.;Curr. Neurovasc. Res.,2004

5. Cerebral anaerobic glycolysis and reduced cerebral oxygen transport in human cerebral malaria;Warrel D. A.;Lancet,1988

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