A bimodal activation mechanism underlies scorpion toxin–induced pain-Reference-Cited by-同舟云学术

A bimodal activation mechanism underlies scorpion toxin–induced pain

Published:2017-08-04 Issue:8 Volume:3 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Yang Shilong¹,Yang Fan²³,Zhang Bei⁴,Lee Bo Hyun³,Li Bowen¹,Luo Lei¹,Zheng Jie³^ORCID,Lai Ren¹^ORCID

Affiliation:

1. Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China.

2. Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.

3. Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA.

4. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.

Abstract

A scorpion toxin uses protons in the venom as coactivators to target nociceptive ion channel TRPV1 and cause pain.

Funder

National Institutes of Health

American Heart Association

National Natural Science Foundation of China

Chinese Academy of Sciences

Ministry of Science and Technology of the People’s Republic of China

Yunnan Province

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference49 articles.

1. The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms

2. Voltage-gated ion channels and gating modifier toxins

3. From Foe to Friend: Using Animal Toxins to Investigate Ion Channel Function

4. Purification, Characterization, and Synthesis of Three Novel Toxins from the Chinese Scorpion Buthus martensi, Which Act on K+ Channels

5. The charybdotoxin family of K+ channel-blocking peptides

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