A specialized flavone biosynthetic pathway has evolved in the medicinal plant, Scutellaria baicalensis

Author:

Zhao Qing1234,Zhang Yang2ORCID,Wang Gang3,Hill Lionel2,Weng Jing-Ke5ORCID,Chen Xiao-Ya146,Xue Hongwei14,Martin Cathie24ORCID

Affiliation:

1. Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai 200032, China.

2. Department of Metabolic Biology, John Innes Centre (JIC), Norwich NR4 7UH, UK.

3. School of Environmental Science and Engineering, Tianjin University, Tianjin 300072, China.

4. CAS-JIC Centre of Excellence for Plant and Microbial Sciences, 300 Feng Lin Road, Shanghai 200032, China.

5. Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

6. Shanghai Chenshan Plant Science Research Center, Chinese Academy of Sciences, Shanghai Chenshan Botanical Garden, Shanghai 201602, China.

Abstract

Scutellaria baicalensis (Huang-Qin in Chinese medicine) produces bioactive 4′-deoxyflavones by a newly evolved metabolic pathway.

Funder

Biotechnology and Biological Sciences Research Council

China Scholarship Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference74 articles.

1. S. Li in Compendium of Materia Medica (Bencao Gangmu) (Huaxia Press China 2012) pp 543–546.

2. Reports for 80 patients with bronchial lung squamous carcinoma (mid or late stage) treated by Lung FuFang and chemotherapy;Pan M. Q.;Journal of Traditional Chinese Medicine and Pharmacy,1990

3. Clinical observation of old people NSCLC (mid or late stage) treated by Lung FuFang combined with chemotherapy;Pan M. Q.;Shanxi Traditional Chinese Medicine,2000

4. Treatmenf of non-small-cell lung cancer by FuZheng anti-cancer prescription combined with chemotherapy;Duan X.;Shanxi Traditional Chinese Medicine,2014

5. New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin;Li-Weber M.;Cancer Treat. Rev.,2009

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