Raman spectroscopy imaging reveals interplay between atherosclerosis and medial calcification in the human aorta

Author:

You Amanda Y. F.123ORCID,Bergholt Mads S.123,St-Pierre Jean-Philippe123,Kit-Anan Worrapong123ORCID,Pence Isaac J.123ORCID,Chester Adrian H.4ORCID,Yacoub Magdi H.4,Bertazzo Sergio5ORCID,Stevens Molly M.123ORCID

Affiliation:

1. Department of Materials, Imperial College London, London SW7 2AZ, UK.

2. Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.

3. Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK.

4. National Heart and Lung Institute, Harefield Heart Science Centre, Imperial College London, Harefield, Middlesex UB9 6JH, UK.

5. Department of Medical Physics and Biomedical Engineering, University College London, Malet Place Engineering Building, London WC1E 6BT, UK.

Abstract

Raman spectroscopy of tissue biochemistry reveals the interplay between atherosclerosis and medial calcification in human aorta.

Funder

Wellcome Trust

H2020 Marie SkÅ?odowska-Curie Actions

Biotechnology and Biological Sciences Research Council

Rosetrees Trust

Biotechnology and Biological Sciences Research Council UK Regenerative Medicine Platform Hubs

Stoneygate Trust

ERC Seventh Framework Programme Consolidator grant “Naturale CG”

Engineering and Physical Sciences Research Council

Medical Research Council

Wellcome Trust and the EPSRC

Wellcome Trust Institutional Strategic Support Fund

Marie Skłodowska-Curie Fellowship

Whitaker International Program, Institute of International Education, United States of America

British Heart Foundation Centre of Research Excellence

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference79 articles.

1. S. Mendis P. Puska B. Norrving Global Atlas on Cardiovascular Disease Prevention and Control (World Health Organization 2011) pp. 2–14.

2. Mortality from ischaemic heart disease by country, region, and age: Statistics from World Health Organisation and United Nations;Finegold J. A.;Int. J. Cardiol.,2013

3. Cardiovascular disease in Europe—Epidemiological update 2015;Townsend N.;Eur. Heart J.,2015

4. Vascular calcification: Pathobiological mechanisms and clinical implications;Johnson R. C.;Circ. Res.,2006

5. Vascular calcification: Pathobiology of a multifaceted disease;Demer L. L.;Circulation,2008

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