Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation

Author:

Fritzsche Marco1,Fernandes Ricardo A.12,Chang Veronica T.13,Colin-York Huw1ORCID,Clausen Mathias P.14ORCID,Felce James H.1ORCID,Galiani Silvia1,Erlenkämper Christoph5ORCID,Santos Ana M.1ORCID,Heddleston John M.6ORCID,Pedroza-Pacheco Isabela7ORCID,Waithe Dominic8,de la Serna Jorge Bernardino18910ORCID,Lagerholm B. Christoffer8,Liu Tsung-li611ORCID,Chew Teng-Leong6,Betzig Eric6ORCID,Davis Simon J.1,Eggeling Christian18

Affiliation:

1. MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford OX3 9DS, UK.

2. Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

3. Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

4. Center for Biomembrane Physics (MEMPHYS), University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.

5. Institut Curie, 26 rue d’Ulm, 75248 Paris cedex 05, France.

6. Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA.

7. Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.

8. Wolfson Imaging Centre, Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford OX3 9DS, UK.

9. Central Laser Facility, Rutherford Appleton Laboratory, Research Complex at Harwell, Science and Technology Facilities Council, Harwell-Oxford Campus, Didcot OX11 0FA, UK.

10. Department of Physics, King’s College London, London WC2R 2LS, UK.

11. Vertex Pharmaceuticals, 11010 Torreyana Road, San Diego, CA 92121, USA.

Abstract

Activating T cells reorganize their cortical actin to form a ramified transportation network beneath the immunological synapse.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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