Reduced evolutionary rate in reemerged Ebola virus transmission chains

Author:

Blackley David J.1,Wiley Michael R.2,Ladner Jason T.2ORCID,Fallah Mosoka3ORCID,Lo Terrence1,Gilbert Merle L.2,Gregory Christopher1,D’ambrozio Jonathan2,Coulter Stewart1ORCID,Mate Suzanne2,Balogun Zephaniah1,Kugelman Jeffrey2,Nwachukwu William1,Prieto Karla2ORCID,Yeiah Adolphus3,Amegashie Fred3,Kearney Brian2ORCID,Wisniewski Meagan2,Saindon John1ORCID,Schroth Gary4,Fakoli Lawrence5,Diclaro Joseph W.6,Kuhn Jens H.7ORCID,Hensley Lisa E.7,Jahrling Peter B.7,Ströher Ute1,Nichol Stuart T.1ORCID,Massaquoi Moses3,Kateh Francis3,Clement Peter8,Gasasira Alex8ORCID,Bolay Fatorma5,Monroe Stephan S.1ORCID,Rambaut Andrew91011,Sanchez-Lockhart Mariano2,Scott Laney A.1,Nyenswah Tolbert3,Christie Athalia1,Palacios Gustavo2ORCID

Affiliation:

1. Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.

2. U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.

3. Ministry of Health, Monrovia, Liberia.

4. Illumina Inc., San Diego, CA 92122, USA.

5. Liberian Institute for Biomedical Research, Charlesville, Liberia.

6. Naval Medical Research Unit No. 3, U.S. Navy, Cairo, Egypt.

7. Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA.

8. World Health Organization, CH-1211 Geneva 27, Switzerland.

9. Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK.

10. Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA.

11. Centre for Immunology, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3FL, UK.

Abstract

Surveillance of Ebola virus disease flare-ups uncovers a reduced rate of Ebola virus evolution during persistent infections.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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