Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5

Author:

Gilbert Andrew S.1ORCID,Seoane Paula I.1ORCID,Sephton-Clark Poppy1ORCID,Bojarczuk Aleksandra23,Hotham Richard23ORCID,Giurisato Emanuele45ORCID,Sarhan Adil R.16ORCID,Hillen Amy7ORCID,Velde Greetje Vande7ORCID,Gray Nathanael S.89,Alessi Dario R.6ORCID,Cunningham Debbie L.1ORCID,Tournier Cathy4ORCID,Johnston Simon A.23,May Robin C.1ORCID

Affiliation:

1. Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

2. Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK.

3. Bateson Centre, University of Sheffield, Sheffield, UK.

4. Division of Molecular and Clinical Cancer, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK.

5. Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.

6. Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland.

7. Biomedical MRI/MoSAIC, Department of Imaging and Pathology, KU Leuven–University of Leuven, Leuven, Belgium.

8. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

9. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, SGM 628, Boston, MA 02115, USA.

Abstract

ERK5 regulates nonlytic expulsion of live pathogens from phagocytes to limit dissemination of infections.

Funder

FP7 People: Marie-Curie Actions

European Research Council

Worldwide Cancer Research

MRC

FWO

Krebs Institute Fellowship

Medical Research Council Center

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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