Robotic QM/MM-driven maturation of antibody combining sites-Reference-Cited by-同舟云学术

Robotic QM/MM-driven maturation of antibody combining sites

Published:2016-10-07 Issue:10 Volume:2 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Smirnov Ivan V.¹,Golovin Andrey V.²^ORCID,Chatziefthimiou Spyros D.³^ORCID,Stepanova Anastasiya V.¹,Peng Yingjie⁴,Zolotareva Olga I.²,Belogurov Alexey A.¹,Kurkova Inna N.¹,Ponomarenko Natalie A.¹,Wilmanns Matthias³,Blackburn G. Michael⁵^ORCID,Gabibov Alexander G.¹²,Lerner Richard A.⁴

Affiliation:

1. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ulitsa Miklukho‐Maklaya 16/10, 117997 Moscow V-437, Russian Federation.

2. Lomonosov Moscow State University, Moscow 119991, Russian Federation.

3. European Molecular Biology Laboratory, Hamburg Unit, c/o German Synchrotron Research Center, Notkestrasse 85, 22603 Hamburg, Germany.

4. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road MB-10, La Jolla, CA 92037, USA.

5. Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, U.K.

Abstract

Robotic QM/MM maturation in silico markedly improved targeted Ig reactivity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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