Tumor-homing peptides as tools for targeted delivery of payloads to the placenta

Author:

King Anna12ORCID,Ndifon Cornelia12ORCID,Lui Sylvia12ORCID,Widdows Kate12,Kotamraju Venkata R.34,Agemy Lilach34,Teesalu Tambet34ORCID,Glazier Jocelyn D.12ORCID,Cellesi Francesco5,Tirelli Nicola56,Aplin John D.12ORCID,Ruoslahti Erkki34,Harris Lynda K.125ORCID

Affiliation:

1. Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester M13 9WL, UK.

2. Academic Health Science Centre, St Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.

3. Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

4. Center for Nanomedicine and Department of Molecular Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106–9610, USA.

5. School of Pharmacy, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

6. Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 9PT, UK.

Abstract

Tumor-homing peptides have been exploited to create nanocarriers for targeted delivery of therapeutic agents to the placenta.

Funder

Biotechnology and Biological Sciences Research Council

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference53 articles.

1. Pregnancy-related mortality from preeclampsia and eclampsia;MacKay A. P.;Obstet. Gynecol.,2001

2. Pre-eclampsia: Pathophysiology, diagnosis, and management;Uzan J.;Vasc. Health Risk Manag.,2011

3. Intrauterine growth retardation;Chiswick M. L.;Br. Med. J.,1985

4. Placental phenotypes of intrauterine growth;Sibley C. P.;Pediatr. Res.,2005

5. Pathology and clinical implications of abnormal umbilical artery Doppler waveforms;Kingdom J. C. P.;Ultrasound Obstet. Gynecol.,1997

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