Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance-Reference-Cited by-同舟云学术

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance

Published:2015-11-06 Issue:10 Volume:1 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Fedorov Oleg¹²^ORCID,Castex Josefina³,Tallant Cynthia¹²,Owen Dafydd R.⁴,Martin Sarah¹²,Aldeghi Matteo¹⁵,Monteiro Octovia¹²,Filippakopoulos Panagis²⁶,Picaud Sarah²,Trzupek John D.⁴^ORCID,Gerstenberger Brian S.⁴,Bountra Chas¹²^ORCID,Willmann Dominica³,Wells Christopher¹²^ORCID,Philpott Martin¹²,Rogers Catherine¹²^ORCID,Biggin Philip C.⁵,Brennan Paul E.¹²^ORCID,Bunnage Mark E.⁴,Schüle Roland³⁷⁸,Günther Thomas³,Knapp Stefan¹²⁸^ORCID,Müller Susanne¹²^ORCID

Affiliation:

1. Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford OX3 7FZ, UK.

2. Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.

3. Urologische Klinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Breisacher Strasse 66, 79106 Freiburg, Germany.

4. Pfizer Worldwide Medicinal Chemistry, 610 Main Street, Cambridge, MA 02139, USA.

5. Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

6. Ludwig Institute for Cancer Research, University of Oxford, Oxford OX3 7DQ, UK.

7. Deutsches Konsortium für Translationale Krebsforschung, Standort Freiburg, 79106 Freiburg, Germany.

8. Institute for Pharmaceutical Chemistry and Buchmann Institute for Molecular Life Sciences, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany.

Abstract

PFI-3, a novel inhibitor targeting the bromodomains of essential components of the BAF/PBAF complex, affects the differentiation of ESC and TSC.

Funder

Wellcome Trust

SGC

Else Kröner-Fresenius-Stiftung

European Research Council

Deutsche Forschungsgemeinschaft

Engineering and Physical Sciences Research Council

DTC

Publisher

American Association for the Advancement of Science (AAAS)