Prefrontal inputs to the amygdala instruct fear extinction memory formation

Author:

Bukalo Olena12,Pinard Courtney R.1ORCID,Silverstein Shana12ORCID,Brehm Christina3,Hartley Nolan D.4,Whittle Nigel3,Colacicco Giovanni1,Busch Erica1,Patel Sachin4,Singewald Nicolas3,Holmes Andrew1

Affiliation:

1. Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20853, USA.

2. Center for Neuroscience and Regenerative Medicine at the Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

3. Department of Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80-82/III, A-6020 Innsbruck, Austria.

4. Department of Psychiatry and Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Abstract

Traumatic fear memories are extinguished by a discrete brain circuit comprising inputs from the prefrontal cortex to the amygdala.

Funder

NIAAA intramural

Department of Defense in the Center for Neuroscience and Regenerative Medicine

Austrian Science Fund

Sonderforschungsbereich

National Institutes of Health

National Institutes on Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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