Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice-Reference-Cited by-同舟云学术

Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice

Published:2017-06-02 Issue:6 Volume:3 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Nakai Nobuhiro¹²³,Nagano Masatoshi⁴,Saitow Fumihito⁴,Watanabe Yasuhito²⁵,Kawamura Yoshinobu²,Kawamoto Akiko²,Tamada Kota¹²,Mizuma Hiroshi⁶,Onoe Hirotaka⁶,Watanabe Yasuyoshi⁶,Monai Hiromu¹,Hirase Hajime¹,Nakatani Jin⁷,Inagaki Hirofumi⁴,Kawada Tomoyuki⁴,Miyazaki Taisuke⁸^ORCID,Watanabe Masahiko⁸^ORCID,Sato Yuka⁹,Okabe Shigeo⁹,Kitamura Kazuo⁹,Kano Masanobu⁹,Hashimoto Kouichi²,Suzuki Hidenori⁴¹⁰,Takumi Toru¹²¹⁰

Affiliation:

1. RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.

2. Graduate School of Biomedical Sciences, Hiroshima University, Minami, Hiroshima 734-8553, Japan.

3. Graduate School of Biostudies, Kyoto University, Sakyo, Kyoto 606-8501, Japan.

4. Graduate School of Medicine, Nippon Medical School, Bunkyo, Tokyo 113-8602, Japan.

5. Department of Clinical Neurobiology, University Hospital and German Cancer Research Center, Heidelberg 69120, Germany.

6. RIKEN Center for Life Science Technologies, Chuo, Kobe 650-0047, Japan.

7. Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan.

8. Department of Anatomy and Embryology, Hokkaido University Graduate School of Medicine, Kita, Sapporo 060-8638, Japan.

9. Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo 113-8654, Japan.

10. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan.

Abstract

Serotonin enhancement during developmental stages restores autism symptoms in a mouse model of human 15q11-13 duplication.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference45 articles.

1. CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics

2. From the genetic architecture to synaptic plasticity in autism spectrum disorder

3. Advancing the understanding of autism disease mechanisms through genetics;de la Torre-Ubieta L.;Nat. Med.,2016

4. Identification of novel autism candidate regions through analysis of reported cytogenetic abnormalities associated with autism;Vorstman J. A. S.;Mol. Psychiatry,2006

5. Rare Inherited and De Novo CNVs Reveal Complex Contributions to ASD Risk in Multiplex Families

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