Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosis

Author:

Cokol Murat¹²³^ORCID,Kuru Nurdan³,Bicak Ece⁴,Larkins-Ford Jonah¹²⁵,Aldridge Bree B.¹²⁶^ORCID

Affiliation:

1. Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA.

2. Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

3. Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul 34956, Turkey.

4. Master of Science Program in Biotechnology, Brandeis University, Waltham, MA 02453, USA.

5. Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.

6. Department of Biomedical Engineering, Tufts University School of Engineering, Medford, MA 02155, USA.

Abstract

Geometrically optimized sampling of drug-dose combinations enables systematic identification of high-order drug synergies.

Funder

NIH Office of the Director

National Institute of General Medical Sciences

Alfred P. Sloan Foundation

The Scientific and Technological Research Council of Turkey

Turkish Academy of Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference34 articles.

1. Drugs and their interactions;Cokol M.;Curr. Drug Discov. Technol.,2013

3. Treatment of tuberculosis;Horsburgh C. R.;N. Engl. J. Med.,2015

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