Syrosingopine sensitizes cancer cells to killing by metformin-Reference-Cited by-同舟云学术

Syrosingopine sensitizes cancer cells to killing by metformin

Published:2016-12-02 Issue:12 Volume:2 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Benjamin Don¹,Colombi Marco¹,Hindupur Sravanth K.¹,Betz Charles¹^ORCID,Lane Heidi A.²^ORCID,El-Shemerly Mahmoud Y. M.²^ORCID,Lu Min³,Quagliata Luca⁴^ORCID,Terracciano Luigi⁴,Moes Suzette¹,Sharpe Timothy¹,Wodnar-Filipowicz Aleksandra⁵,Moroni Christoph¹^ORCID,Hall Michael N.¹

Affiliation:

1. Biozentrum, University of Basel, 4056 Basel, Switzerland.

2. Basilea Pharmaceutica International Ltd., Basel, Switzerland.

3. Institute for Medical Microbiology, University of Basel, 4003 Basel, Switzerland.

4. Molecular Pathology, University Hospital Basel, 4003 Basel, Switzerland.

5. Stem Cell Center of Competence, University of Basel, 4056 Basel, Switzerland.

Abstract

Synthetic lethality between the clinically approved noncancer drugs metformin and syrosingopine specifically kills cancer cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference62 articles.

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4. Metformin and cancer risk in diabetic patients: A systematic review and meta-analysis;Decensi A.;Cancer Prev. Res.,2010

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