Solving protein structures using short-distance cross-linking constraints as a guide for discrete molecular dynamics simulations-Reference-Cited by-同舟云学术

Solving protein structures using short-distance cross-linking constraints as a guide for discrete molecular dynamics simulations

Published:2017-07-07 Issue:7 Volume:3 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Brodie Nicholas I.¹,Popov Konstantin I.²,Petrotchenko Evgeniy V.¹,Dokholyan Nikolay V.²^ORCID,Borchers Christoph H.¹³⁴⁵^ORCID

Affiliation:

1. University of Victoria–Genome British Columbia Proteomics Centre, Vancouver Island Technology Park, #3101-4464 Markham Street, Victoria, British Columbia V8Z7X8, Canada.

2. Department of Biochemistry and Biophysics, University of North Carolina, Genetic Medicine Building, 120 Mason Farm Road, Chapel Hill, NC 27599, USA.

3. Department of Biochemistry and Microbiology, University of Victoria, Room 270d, Petch Building, 3800 Finnerty Road, Victoria, British Columbia V8P 5C2, Canada.

4. Gerald Bronfman Department of Oncology, Jewish General Hospital, Suite 720, 5100 de Maisonneuve Boulevard West, Montreal, Quebec H4A 3T2, Canada.

5. Proteomics Centre, Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University, 3755 Côte-Sainte-Catherine Road, Montreal, Quebec H3T 1E2, Canada.

Abstract

Short-distance cross-linking constraints combined with discrete molecular dynamics enable rapid prediction of protein structures.

Funder

Genome Canada

Genome BC

National Institutes of Health

Natural Sciences and Engineering Research Council of Canada

Leading Edge Endowment Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary