Enzymatically active biomimetic micropropellers for the penetration of mucin gels-Reference-Cited by-同舟云学术

Enzymatically active biomimetic micropropellers for the penetration of mucin gels

Published:2015-12-04 Issue:11 Volume:1 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Walker Debora¹²^ORCID,Käsdorf Benjamin T.³,Jeong Hyeon-Ho¹,Lieleg Oliver³,Fischer Peer¹²

Affiliation:

1. Max Planck Institute for Intelligent Systems, Heisenbergstrasse 3, 70569 Stuttgart, Germany.

2. Institute for Physical Chemistry, University of Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Germany.

3. Institute for Medical Engineering and Department of Mechanical Engineering, Technische Universität München, Boltzmannstrasse 11, 85748 Garching, Germany.

Abstract

Magnetic microparticles decorated with enzymes can penetrate mucin, which is a barrier for most particle-based drug carriers.

Funder

European Research Council

Deutsche Forschungsgemeinschaft

Baden-Württemberg Stiftung

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference64 articles.

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2. Micro- and macrorheology of mucus

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4. Rheology of gastric mucin exhibits a pH-dependent sol–gel transition;Celli J. P.;Biomacromolecules,2007

5. Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers

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