Vasculogenic hydrogel enhances islet survival, engraftment, and function in leading extrahepatic sites

Author:

Weaver Jessica D.12ORCID,Headen Devon M.12,Aquart Jahizreal2,Johnson Christopher T.23ORCID,Shea Lonnie D.45,Shirwan Haval67ORCID,García Andrés J.12

Affiliation:

1. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.

2. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332, USA.

3. Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA, 30332, USA.

4. Department of Biomedical Engineering and Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.

5. Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Suite 03-2303, 250 East Superior Street, Chicago, IL 60611, USA.

6. Institute of Cellular Therapeutics, Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY, 40202, USA.

7. FasCure Therapeutics LLC, 300 East Market Street, Louisville, KY 40202, USA.

Abstract

VEGF-delivering synthetic hydrogel improves islet survival and function in extrahepatic transplant sites over current clinical method.

Funder

Juvenile Diabetes Research Foundation International

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference55 articles.

1. Global prevalence of diabetes estimates for the year 2000 and projections for 2030;Wild S.;Diabetes Care,2004

2. Center for Disease Control “National diabetes fact sheet: National estimates and general information on diabetes and prediabetes in the United States 2011” (CDC 2011); https://www.cdc.gov/diabetes/pubs/pdf/ndfs_2011.pdf.

3. Perspectives in pancreatic and islet cell transplantation for the therapy of IDDM;Calafiore R.;Diabetes Care,1997

4. Islet cell transplantation for the treatment of type 1 diabetes: Recent advances and future challenges;Bruni A.;Diabetes Metab. Syndr. Obes. Target Ther.,2014

5. Pancreatectomy and autologous islet transplantation for painful chronic pancreatitis: Indications and outcomes;Bellin M. D.;Hosp. Pract.,2012

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