Key role of the dopamine D 4 receptor in the modulation of corticostriatal glutamatergic neurotransmission

Author:

Bonaventura Jordi1ORCID,Quiroz César1,Cai Ning-Sheng1,Rubinstein Marcelo2,Tanda Gianluigi3ORCID,Ferré Sergi1

Affiliation:

1. Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.

2. Institute of Investigation in Genetic Engineering and Molecular Biology, Buenos Aires 1428, Argentina.

3. Medications Development Program, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.

Abstract

The function of the dopamine D 4 receptor and the product of a clinically significant gene polymorphic variant is revealed.

Funder

National Institute on Drug Abuse

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference32 articles.

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2. The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus;Wang E.;Am. J. Hum. Genet.,2004

3. The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus;Chang F.-M.;Hum. Genet.,1996

4. Molecular genetics of attention-deficit/hyperactivity disorder;Faraone S. V.;Biol. Psychiatry,2005

5. Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD);Li D.;Hum. Mol. Genet.,2006

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