Serine one-carbon catabolism with formate overflow-Reference-Cited by-同舟云学术

Serine one-carbon catabolism with formate overflow

Published:2016-10-07 Issue:10 Volume:2 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Meiser Johannes¹^ORCID,Tumanov Sergey¹²^ORCID,Maddocks Oliver²,Labuschagne Christiaan Fred¹,Athineos Dimitris¹^ORCID,Van Den Broek Niels¹,Mackay Gillian M.¹,Gottlieb Eyal¹^ORCID,Blyth Karen¹,Vousden Karen¹,Kamphorst Jurre J.¹²,Vazquez Alexei¹

Affiliation:

1. Cancer Research UK Beatson Institute, Glasgow, UK

2. Institute of Cancer Sciences, University of Glasgow, Glasgow, UK

Abstract

Serine catabolism results in formate efflux that exceeds anabolic demands for purine synthesis.

Funder

Cancer Research UK

DFG Fellowship Grant

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference31 articles.

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4. One-carbon metabolism in lectin-activated human-lymphocytes;Rowe P. B.;Arch. Biochem. Biophys.,1985

5. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

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