Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase-Reference-Cited by-同舟云学术

Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase

Author:

Deville Célia¹^ORCID,Carroni Marta¹^ORCID,Franke Kamila B.²,Topf Maya¹^ORCID,Bukau Bernd²,Mogk Axel²^ORCID,Saibil Helen R.¹^ORCID

Affiliation:

1. Department of Crystallography, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.

2. Center for Molecular Biology of the Heidelberg University, German Cancer Research Center, Heidelberg, Germany.

Abstract

Cryo-EM structures of ClpB complexes reveal a pathway for substrate transfer and translocation during protein disaggregation.

Funder

Wellcome Trust

Medical Research Council

Biotechnology and Biological Sciences Research Council

Deutsche Forschungsgemeinschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

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