A novel GABA-mediated corticotropin-releasing hormone secretory mechanism in the median eminence

Author:

Kakizawa Keisuke12,Watanabe Miho1,Mutoh Hiroki1,Okawa Yuta12,Yamashita Miho2,Yanagawa Yuchio3,Itoi Keiichi4,Suda Takafumi2,Oki Yutaka5,Fukuda Atsuo1

Affiliation:

1. Department of Neurophysiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.

2. Second Division, Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.

3. Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.

4. Laboratory of Information Biology, Graduate School of Information Sciences, Tohoku University, Sendai, Miyagi 980-8579, Japan.

5. Department of Family and Community Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.

Abstract

Excitatory GABAergic input from arcuate nucleus maintains steady-state CRH release from axon terminals with NKCC1-driven high [Cl ] i .

Funder

Ministry of Education, Culture, Sports, Science, and Technology

Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference64 articles.

1. Neuropeptides in the hypothalamo-hypophyseal system: Lateral retrochiasmatic area as a common gate for neuronal fibers towards the median eminence;Palkovits M.;Peptides,1984

2. Ultrastructural characteristics of immunolabelled, corticotropin releasing factor (CRF)-synthesizing neurons in the rat brain;Liposits Z.;Cell Tissue Res.,1983

3. B. H. Levy, J. G. Tasker, Synaptic regulation of the hypothalamic–pituitary–adrenal axis and its modulation by glucocorticoids and stress. Front. Cell. Neurosci. 6, 1–13 (2012).

4. Two genes encode distinct glutamate decarboxylases

5. Local origins of some GABAergic projections to the paraventricular and supraoptic nuclei of the hypothalamus in the rat;Roland B. L.;J. Comp. Neurol.,1993

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