Clinically relevant mutations in core metabolic genes confer antibiotic resistance-Reference-Cited by-同舟云学术

Clinically relevant mutations in core metabolic genes confer antibiotic resistance

Published:2021-02-19 Issue:6531 Volume:371 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lopatkin Allison J.¹²³⁴⁵^ORCID,Bening Sarah C.¹²^ORCID,Manson Abigail L.²^ORCID,Stokes Jonathan M.¹²³,Kohanski Michael A.⁶^ORCID,Badran Ahmed H.²^ORCID,Earl Ashlee M.²^ORCID,Cheney Nicole J.⁷⁸^ORCID,Yang Jason H.⁷⁸^ORCID,Collins James J.¹²³⁹¹⁰^ORCID

Affiliation:

1. Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.

2. Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

3. Wyss Institute for Biologically Inspired Engineering; Harvard University, Boston, MA, USA.

4. Department of Biology, Barnard College, New York, NY, USA.

5. Data Science Institute, Columbia University, New York, NY, USA.

6. Department of Otorhinolaryngology-Head and Neck Surgery, Division of Rhinology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

7. Ruy V. Lourenço Center for Emerging and Re-Emerging Pathogens, Rutgers New Jersey Medical School, Newark, NJ, USA.

8. Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ, USA.

9. Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA, USA.

10. Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.

Abstract

The many roads to resistance Antibiotic resistance arising from mutation is common among pathogenic bacteria. However, this process is not well understood, and most of the mutations that have been identified to confer resistance do so by modification of the intracellular target or enzymes that can disable the antibacterial compound within the cell. Screening for the evolution of resistance at different temperatures, Lopatkin et al. found that mutations that affect microbial metabolism can result in antibiotic resistance (see the Perspective by Zampieri). These mutations targeted central carbon and energy metabolism and revealed novel resistance mutations in core metabolic genes, expanding the known means by which pathogenic microbes can evolve resistance. Science , this issue p. eaba0862 ; see also p. 783

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Defense Threat Reduction Agency

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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