Regeneration of fat cells from myofibroblasts during wound healing-Reference-Cited by-同舟云学术

Regeneration of fat cells from myofibroblasts during wound healing

Published:2017-02-17 Issue:6326 Volume:355 Page:748-752
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Plikus Maksim V.¹²^ORCID,Guerrero-Juarez Christian F.²^ORCID,Ito Mayumi³,Li Yun Rose⁴^ORCID,Dedhia Priya H.⁵,Zheng Ying¹^ORCID,Shao Mengle⁶^ORCID,Gay Denise L.¹⁷^ORCID,Ramos Raul²,Hsi Tsai-Ching²,Oh Ji Won²⁸^ORCID,Wang Xiaojie²,Ramirez Amanda²^ORCID,Konopelski Sara E.²,Elzein Arijh²^ORCID,Wang Anne¹^ORCID,Supapannachart Rarinthip June¹,Lee Hye-Lim²,Lim Chae Ho³,Nace Arben¹^ORCID,Guo Amy¹^ORCID,Treffeisen Elsa¹,Andl Thomas⁹,Ramirez Ricardo N.²^ORCID,Murad Rabi²,Offermanns Stefan¹⁰,Metzger Daniel¹¹^ORCID,Chambon Pierre¹²,Widgerow Alan D.¹³^ORCID,Tuan Tai-Lan¹⁴^ORCID,Mortazavi Ali²,Gupta Rana K.⁶,Hamilton Bruce A.¹⁵,Millar Sarah E.¹,Seale Patrick⁴¹⁶,Pear Warren S.⁵^ORCID,Lazar Mitchell A.⁴¹⁷^ORCID,Cotsarelis George¹^ORCID

Affiliation:

1. Department of Dermatology, Kligman Laboratories, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.

3. The Ronald O. Perelman Department of Dermatology, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.

4. The Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

5. Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

6. Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

7. INSERM U967, Commissariat à L’énergie Atomique et aux Énergies Alternatives, Institut de Radiobiologie Cellulaire et Moléculaire 92265 Fontenay-aux-Roses Cedex, France.

8. Department of Anatomy, School of Medicine, Kyungpook National University, Daegu, Korea.

9. Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 328116, USA.

10. Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim 61231, Germany.

11. Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR7104, INSERM U964, Université de Strasbourg, Illkirch 67404, France.

12. Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR7104, INSERM U964, Institut d’Etudes Avancées de l’Université de Strasbourg, Collège de France, Illkirch 67404, France.

13. Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, Irvine, CA 92868, USA.

14. The Saban Research Institute of Children’s Hospital Los Angeles and Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.

15. Departments of Medicine and Cellular and Molecular Medicine, Moores Cancer Center and Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

16. Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

17. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Hair follicles: Secret to prevent scars? Although some animals easily regenerate limbs and heal broken flesh, mammals are generally not so gifted. Wounding can leave scars, which are characterized by a lack of hair follicles and cutaneous fat. Plikus et al. now show that hair follicles in both mice and humans can convert myofibroblasts, the predominant dermal cell in a wound, into adipocytes (see the Perspective by Chan and Longaker). The hair follicles activated the bone morphogenetic protein (BMP) signaling pathway and adipocyte transcription factors in the myofibroblast. Thus, it may be possible to reduce scar formation after wounding by adding BMP. Science , this issue p. 748 ; see also p. 693

Funder

National Science Foundation

National Cancer Institute

National Institute of General Medical Sciences

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Pew Charitable Trusts

California Institute for Regenerative Medicine

Dermatology Foundation

Canadian Institutes of Health Research

Publisher

American Association for the Advancement of Science (AAAS)