Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves T H 1/T FH fate bifurcation in malaria-Reference-Cited by-同舟云学术

Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves T H 1/T FH fate bifurcation in malaria

Published:2017-03-31 Issue:9 Volume:2 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Lönnberg Tapio¹²^ORCID,Svensson Valentine¹^ORCID,James Kylie R.³^ORCID,Fernandez-Ruiz Daniel⁴^ORCID,Sebina Ismail³,Montandon Ruddy²,Soon Megan S. F.³^ORCID,Fogg Lily G.³,Nair Arya Sheela³,Liligeto Urijah N.³,Stubbington Michael J. T.¹²^ORCID,Ly Lam-Ha²,Bagger Frederik Otzen¹²⁵⁶^ORCID,Zwiessele Max⁷,Lawrence Neil D.⁷^ORCID,Souza-Fonseca-Guimaraes Fernando³,Bunn Patrick T.³,Engwerda Christian R.³^ORCID,Heath William R.⁴⁸^ORCID,Billker Oliver²^ORCID,Stegle Oliver¹^ORCID,Haque Ashraful³^ORCID,Teichmann Sarah A.¹²^ORCID

Affiliation:

1. European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, U.K.

2. Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, U.K.

3. QIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland, Australia.

4. Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Parkville, Victoria, Australia.

5. Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, U.K.

6. National Health Service Blood and Transplant, Cambridge Biomedical Campus, Long Road, Cambridge, U.K.

7. Department of Computer Science, University of Sheffield, Sheffield, U.K.

8. Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Parkville, Victoria, Australia.

Abstract

Computational modeling defines T helper cell differentiation toward multiple fates during experimental malaria.

Funder

Wellcome Trust

European Research Council

University of Queensland

Marie Curie ITN

Australian National Health and Medical Research Council Project gran

Australian National Health and Medical Research Council Career Development Fellowship

Australian Infectious Disease Research Centre

Lister Institute for Preventative Medicine

EMBL Australia

OzEMalaR

Lundbeck Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference64 articles.

1. World Malaria Report 2016 (World Health Organization 2016).

2. Low doses of killed parasite in CpG elicit vigorous CD4+ T cell responses against blood-stage malaria in mice

3. Human Antibodies Fix Complement to Inhibit Plasmodium falciparum Invasion of Erythrocytes and Are Associated with Protection against Malaria

4. Circulating Th1-Cell-type Tfh Cells that Exhibit Impaired B Cell Help Are Preferentially Activated during Acute Malaria in Children

5. CD4 T-Cell Subsets in Malaria: TH1/TH2 Revisited

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