CD1d-Restricted and TCR-Mediated Activation of V α 14 NKT Cells by Glycosylceramides-Reference-Cited by-同舟云学术

CD1d-Restricted and TCR-Mediated Activation of V α 14 NKT Cells by Glycosylceramides

Published:1997-11-28 Issue:5343 Volume:278 Page:1626-1629
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kawano Tetsu¹²,Cui Junqing¹²,Koezuka Yasuhiko¹²,Toura Isao¹²,Kaneko Yoshikatsu¹²,Motoki Kazuhiro¹²,Ueno Hitomi¹²,Nakagawa Ryusuke¹²,Sato Hiroshi¹²,Kondo Eisuke¹²,Koseki Haruhiko¹²,Taniguchi Masaru¹²

Affiliation:

1. T. Kawano, J. Cui, I. Toura, Y. Kaneko, H. Sato, E. Kondo, H. Koseki, M. Taniguchi, CREST (Core Research for Evolutional Science and Technology) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260, Japan.

2. Y. Koezuka, K. Motoki, H. Ueno, R. Nakagawa, Pharmaceutical Research Laboratory, Kirin Brewery, 3 Miyahara, Takasaki, Gunma 370-12, Japan.

Abstract

Natural killer T (NKT) lymphocytes express an invariant T cell antigen receptor (TCR) encoded by the V α 14 and J α 281 gene segments. A glycosylceramide-containing α-anomeric sugar with a longer fatty acyl chain (C 26 ) and sphingosine base (C 18 ) was identified as a ligand for this TCR. Glycosylceramide-mediated proliferative responses of V α 14 NKT cells were abrogated by treatment with chloroquine–concanamycin A or by monoclonal antibodies against CD1d/V β 8, CD40/CD40L, or B7/CTLA-4/CD28, but not by interference with the function of a transporter-associated protein. Thus, this lymphocyte shares distinct recognition systems with either T or NK cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference58 articles.

1. Y. Makino R. Kanno H. Koseki M. Taniguchi Proc. Natl. Acad. Sci. U.S.A . 93 6516 (1996).

2. Imai K., et al., ibid. 83, 8708 (1986);

3. Koseki H., Imai K., Ichikawa T., Hayata I., Taniguchi M., Int. Immunol. 6, 557 (1989);

4. Lantz O., Bendelac A., J. Exp. Med. 180, 1097 (1994).

5. Makino Y., Kanno R., Ito T., Higashino K., Taniguchi M., Int. Immunol. 7, 1157 (1995).

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