Requirement of Math1 for Secretory Cell Lineage Commitment in the Mouse Intestine-Reference-Cited by-同舟云学术

Requirement of Math1 for Secretory Cell Lineage Commitment in the Mouse Intestine

Published:2001-12-07 Issue:5549 Volume:294 Page:2155-2158
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Yang Qi¹,Bermingham Nessan A.²³,Finegold Milton J.⁴,Zoghbi Huda Y.¹²³

Affiliation:

1. Department of Pediatrics and Program in Developmental Biology,

2. Department of Molecular and Human Genetics,

3. Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA.

4. Department of Pathology and

Abstract

The mouse small intestinal epithelium consists of four principal cell types deriving from one multipotent stem cell: enterocytes, goblet, enteroendocrine, and Paneth cells. Previous studies showed that Math1 , a basic helix-loop-helix (bHLH) transcription factor, is expressed in the gut. We find that loss of Math1 leads to depletion of goblet, enteroendocrine, and Paneth cells without affecting enterocytes. Colocalization of Math1 with Ki-67 in some proliferating cells suggests that secretory cells (goblet, enteroendocrine, and Paneth cells) arise from a common progenitor that expresses Math1 , whereas absorptive cells (enterocytes) arise from a progenitor that is Math1 -independent. The continuous rapid renewal of these cells makes the intestinal epithelium a model system for the study of stem cell regeneration and lineage commitment.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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