Modulation of Cell Proliferation by Heterotrimeric G Protein in Arabidopsis-Reference-Cited by-同舟云学术

Modulation of Cell Proliferation by Heterotrimeric G Protein in Arabidopsis

Published:2001-06-15 Issue:5524 Volume:292 Page:2066-2069
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ullah Hemayet¹,Chen Jin-Gui¹,Young Jeff C.²,Im Kyung-Hoan¹,Sussman Michael R.²,Jones Alan M.¹

Affiliation:

1. Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

2. Cell and Molecular Biology Program and the Department of Horticulture, University of Wisconsin, 1575 Linden Drive, Madison, WI 53706, USA.

Abstract

The α subunit of a prototypical heterotrimeric GTP-binding protein (G protein), which is encoded by a single gene ( GPA1 ) in Arabidopsis , is a modulator of plant cell proliferation. gpa1 null mutants have reduced cell division in aerial tissues throughout development. Inducible overexpression of GPA1 in Arabidopsis confers inducible ectopic cell division. GPA1 overexpression in synchronized BY-2 cells causes premature advance of the nuclear cycle and the premature appearance of a division wall. Results from loss of function and ectopic expression and activation of GPA1 indicate that this subunit is a positive modulator of cell division in plants.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference33 articles.

1. The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades

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4. G Protein-Coupled Receptor Systems Involved in Cell Growth and Oncogenesis

5. Regulation of the Differentiation of Teratocarcinoma Cells into Primitive Endoderm by Gβ i2

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