A Brief History of Drosophila 's Contributions to Genome Research-Reference-Cited by-同舟云学术

A Brief History of Drosophila 's Contributions to Genome Research

Published:2000-03-24 Issue:5461 Volume:287 Page:2216-2218
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Rubin Gerald M.¹,Lewis Edward B.²

Affiliation:

1. Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720–3200, USA.

2. Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

Abstract

The sequence of the Drosophila melanogaster genome presented in this issue of Science is the latest milestone in nine decades of research on this organism. Genetic and physical mapping, whole-genome mutational screens, and functional alteration of the genome by gene transfer were pioneered in metazoans with the use of this small fruit fly. Here we look at some of the instances in which work on Drosophila has led to major conceptual or technical breakthroughs in our understanding of animal genomes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference51 articles.

1. Sturtevant A. H., Am. Sci. 53, 303 (1965);

2. ; A. H. Sturtevant A History of Genetics (Harper and Row New York 1965) pp. 1–167; H. L. K. Whitehouse Towards an Understanding of the Mechanism of Heredity (Arnold London ed. 2 1969) pp. 1–447.

3. Sturtevant A. H., J. Exp. Zool. 14, 43 (1913).

4. Direct Proof Through Non-Disjunction That the Sex-Linked Genes of Drosophila Are Borne by the X-Chromosome

5. ; Genetics 1 1 (1916).

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