From Sequence to Chromosome: The Tip of the X Chromosome of D. melanogaster-Reference-Cited by-同舟云学术

From Sequence to Chromosome: The Tip of the X Chromosome of D. melanogaster

Published:2000-03-24 Issue:5461 Volume:287 Page:2220-2222
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Benos Panayiotis V.¹,Gatt Melanie K.²³,Ashburner Michael¹²,Murphy Lee⁴,Harris David⁴,Barrell Bart⁴,Ferraz Concepcion⁵,Vidal Sophie⁵,Brun Christine⁵,Demailles Jacques⁵,Cadieu Edouard⁶,Dreano Stephane⁶,Gloux Stéphanie⁶,Lelaure Valerie⁶,Mottier Stephanie⁶,Galibert Francis⁶,Borkova Dana⁷,Minana Belen⁷,Kafatos Fotis C.⁷,Louis Christos⁸⁹,Sidén-Kiamos Inga⁸,Bolshakov Slava⁷⁸,Papagiannakis George⁸,Spanos Lefteris⁸,Cox Sarah⁸,Madueño Encarnación¹⁰,Pablos Beatriz de¹⁰,Modolell Juan¹⁰,Peter Annette¹¹,Schöttler Petra¹¹,Werner Meike¹¹,Mourkioti Foteini¹¹,Beinert Nicole¹¹,Dowe Gordon¹¹,Schäfer Ulrich¹¹,Jäckle Herbert¹¹,Bucheton Alain⁵,Callister Deborah M.³,Campbell Lorna A.³,Darlamitsou Areti³,Henderson Nadine S.³,McMillan Paul J.³,Salles Cathy³,Tait Evelyn A.³,Valenti Phillipe³,C. Robert D.,Saunders ³¹²,Glover David M.²³

Affiliation:

1. The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton Hall, Cambridge CB10 1SD, UK.

2. Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.

3. Department of Anatomy and Physiology, Cancer Research Campaign Cell Cycle Genetics Group, University of Dundee, Dundee DD1 4HN, UK.

4. Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

5. Montpellier University Medical School, Institut de Génétique Humaine (IGH), CNRS, 114 Rue de la Cardonille, 34396 Montpellier Cedex 5, France.

6. UnitéPropre de Recherche 41, CNRS, Recombinaisons Genetiques, Faculte de Medecine, 2 Avenue du Pr Leon Bernard, 35043 Rennes Cedex, France.

7. European Molecular Biology Laboratory, Heidelberg, Germany.

8. Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology–Hellas, Heraklion, Greece.

9. Department of Biology, University of Crete, Heraklion, Greece.

10. Centro de Biologı́a Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientifı́cas and Universidad Autónoma de Madrid, 28049 Madrid, Spain.

11. Max-Planck-Institut für Biophysikalische Chemie, Department of Molecular Developmental Biology, D-37070 Göttingen, Germany.

12. Department of Biological Sciences, The Open University, Milton Keynes MK7 6AA, UK.

Abstract

One of the rewards of having a Drosophila melanogaster whole-genome sequence will be the potential to understand the molecular bases for structural features of chromosomes that have been a long-standing puzzle. Analysis of 2.6 megabases of sequence from the tip of the X chromosome of Drosophila identifies 273 genes. Cloned DNAs from the characteristic bulbous structure at the tip of the X chromosome in the region of the broad complex display an unusual pattern of in situ hybridization. Sequence analysis revealed that this region comprises 154 kilobases of DNA flanked by 1.2-kilobases of inverted repeats, each composed of a 350–base pair satellite related element. Thus, some aspects of chromosome structure appear to be revealed directly within the DNA sequence itself.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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