Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes-Reference-Cited by-同舟云学术

Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes

Published:2009-10-02 Issue:5949 Volume:326 Page:150-153
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Cadieu Edouard¹,Neff Mark W.²,Quignon Pascale¹,Walsh Kari²,Chase Kevin³,Parker Heidi G.¹,VonHoldt Bridgett M.⁴,Rhue Alison²,Boyko Adam⁵,Byers Alexandra¹,Wong Aaron²,Mosher Dana S.¹,Elkahloun Abdel G.¹,Spady Tyrone C.¹,André Catherine⁶,Lark K. Gordon³,Cargill Michelle⁷,Bustamante Carlos D.⁵,Wayne Robert K.⁴,Ostrander Elaine A.¹

Affiliation:

1. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

2. Veterinary Genetics Laboratory, University of California, Davis, CA, 95616, USA.

3. Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.

4. Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, 90095, USA.

5. Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA.

6. UMR 6061, CNRS, Université de Rennes 1, Faculté de Médecine, CS 34317, Rennes, France.

7. Affymetrix Corporation, Santa Clara, CA 95051, USA.

Abstract

Dog Coats Shed Genetic Secrets The coats of domestic dogs show great variation—long, short, straight, wavy, curly, wiry, or smooth. To investigate how this variation arises, Cadieu et al. (p. 150 , published online 27 August) performed genome-wide association studies on 80 different dog breeds. The coat phenotype could be dissected into three simple traits of length, curl, and growth pattern or texture with each trait controlled by one major gene, FGF5 (fibroblast growth factor-5), KRT71 (keratin-71), and RSPO2 (R-spondin-2), respectively. In combination, variants in these three genes alone account for the vast majority of the coat phenotypes in purebred dogs in the United States. Thus, a small number of simply inherited traits can be remixed to create extraordinary phenotypic variation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference26 articles.

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3. A Single IGF1 Allele Is a Major Determinant of Small Size in Dogs

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5. Genome sequence, comparative analysis and haplotype structure of the domestic dog

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