Liver type 1 innate lymphoid cells develop locally via an interferon-γ–dependent loop

Author:

Bai Lu12ORCID,Vienne Margaux3ORCID,Tang Ling12ORCID,Kerdiles Yann3ORCID,Etiennot Marion3,Escalière Bertrand3,Galluso Justine3,Wei Haiming124ORCID,Sun Rui124ORCID,Vivier Eric356ORCID,Peng Hui124ORCID,Tian Zhigang124ORCID

Affiliation:

1. Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

2. Institute of Immunology, University of Science and Technology of China, Hefei, China.

3. Aix Marseille Univ., CNRS, INSERM, CIML, Marseille, France.

4. Research Unit for NK Cell Study, Chinese Academy of Medical Sciences, Beijing, China.

5. APHM, Hôpital de la Timone, Marseille-Immunopole, Marseille, France.

6. Innate Pharma, Marseille, France.

Abstract

An IFN-γ feedback loop Innate lymphoid cells (ILCs) play important roles in tissue homeostasis and host defense. Type 1 ILCs (ILC1s) produce interferon-γ (IFN-γ) and require the transcriptional master regulator T-bet. The pathways underlying how these cells develop and differentiate have remained poorly understood. Bai et al. found that the adult mouse liver contains a population of Lin–Sca-1 + Mac-1 + hematopoietic stem cells (LSM HSCs) that preferentially differentiate into tissue-resident liver ILC1s. They further show that IFN-γ produced by mature ILC1s promotes the expansion and differentiation of LSM HSCs into ILC1s but not natural killer cells. This work expands our understanding of extramedullary hematopoiesis and underscores the unique immune status of the liver. Science , this issue p. eaba4177

Funder

H2020 European Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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