Translocation of Helicobacter pylori CagA into Gastric Epithelial Cells by Type IV Secretion-Reference-Cited by-同舟云学术

Translocation of Helicobacter pylori CagA into Gastric Epithelial Cells by Type IV Secretion

Published:2000-02-25 Issue:5457 Volume:287 Page:1497-1500
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Odenbreit Stefan¹,Püls Jürgen¹,Sedlmaier Bettina¹,Gerland Elke¹,Fischer Wolfgang¹,Haas Rainer¹

Affiliation:

1. Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig-Maximilians University Munich, D-80336 Munich, Germany.

Abstract

The Gram-negative bacterium Helicobacter pylori is a causative agent of gastritis and peptic ulcer disease in humans. Strains producing the CagA antigen ( cagA + ) induce strong gastric inflammation and are strongly associated with gastric adenocarcinoma and MALT lymphoma. We show here that such strains translocate the bacterial protein CagA into gastric epithelial cells by a type IV secretion system, encoded by the cag pathogenicity island. CagA is tyrosine-phosphorylated and induces changes in the tyrosine phosphorylation state of distinct cellular proteins. Modulation of host cells by bacterial protein translocation adds a new dimension to the chronic Helicobacter infection with yet unknown consequences.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference28 articles.

1. M. J. Blaser Sci. Am. 274 104 (February 1996).

2. Z. Y. Xiang et al. Infect. Immun. 63 94 (1995).

3. Segal E. D., Falkow S., Tompkins L. S., Proc. Natl. Acad. Sci. U.S.A. 93, 1259 (1996).

4. S. Censini et al. Proc. Natl. Acad. Sci. U.S.A. 93 14648 (1996).

5. Segal E. D., Lange C., Covacci A., Tompkins L. S., Falkow S., Proc. Natl. Acad. Sci. U.S.A. 94, 7595 (1997).

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