Breakdown of Cortical Effective Connectivity During Sleep-Reference-Cited by-同舟云学术

Breakdown of Cortical Effective Connectivity During Sleep

Published:2005-09-30 Issue:5744 Volume:309 Page:2228-2232
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Massimini Marcello¹²,Ferrarelli Fabio¹²,Huber Reto¹²,Esser Steve K.¹²,Singh Harpreet¹²,Tononi Giulio¹²

Affiliation:

1. Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA.

2. Department of Clinical Sciences, University of Milan, via G. B. Grassi 74, Milan 20157, Italy.

Abstract

When we fall asleep, consciousness fades yet the brain remains active. Why is this so? To investigate whether changes in cortical information transmission play a role, we used transcranial magnetic stimulation together with high-density electroencephalography and asked how the activation of one cortical area (the premotor area) is transmitted to the rest of the brain. During quiet wakefulness, an initial response (∼15 milliseconds) at the stimulation site was followed by a sequence of waves that moved to connected cortical areas several centimeters away. During non–rapid eye movement sleep, the initial response was stronger but was rapidly extinguished and did not propagate beyond the stimulation site. Thus, the fading of consciousness during certain stages of sleep may be related to a breakdown in cortical effective connectivity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

1. Brain-Mind States: I. Longitudinal Field Study of Sleep/Wake Factors Influencing Mentation Report Length

2. Natural Waking and Sleep States: A View From Inside Neocortical Neurons

3. Coherence analysis of the human sleep electroencephalogram

4. Thalamocortical Oscillations in the Sleeping and Aroused Brain

5. Gamma activity and synchrony which have been viewed as possible correlates of consciousness ( 26 – 28 ) were found to be low in NREM sleep in one study ( 29 ). However they were equally low in REM sleep when conscious experience is usually vivid and they can be high during anesthesia ( 30 ). Moreover intracellular recordings show that gamma activity persists during NREM sleep ( 31 ) and other studies report that gamma coherence is a local phenomenon that does not change between wakefulness and sleep ( 32 ). Large-scale synchrony in the alpha and theta bands may also correlate with conscious perception during wakefulness ( 33 ) but synchrony in these frequency bands actually increases during NREM sleep ( 3 34 ).

Cited by 1248 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Altered sleep onset transition in depression: Evidence from EEG activity and EEG functional connectivity analyses;Clinical Neurophysiology;2024-10

2. Whole-brain turbulent dynamics predict responsiveness to pharmacological treatment in major depressive disorder;Molecular Psychiatry;2024-09-10

3. Using TMS-EEG to study the intricate interplay between GABAergic inhibition and glutamatergic excitation during reactive and proactive motor inhibition;2024-09-05

4. Reduced TMS-evoked EEG oscillatory activity in cortical motor regions in patients with post-COVID fatigue;Clinical Neurophysiology;2024-09

5. Behavioral and Electrophysiological Markers of Attention Fluctuations in Children with Hypersomnolence;Journal of Clinical Medicine;2024-08-27