Deterministic reprogramming of neutrophils within tumors-Reference-Cited by-同舟云学术

Deterministic reprogramming of neutrophils within tumors

Published:2024-01-12 Issue:6679 Volume:383 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ng Melissa S. F.¹^ORCID,Kwok Immanuel¹^ORCID,Tan Leonard¹^ORCID,Shi Changming²^ORCID,Cerezo-Wallis Daniela³⁴,Tan Yingrou¹⁵^ORCID,Leong Keith¹^ORCID,Calvo Gabriel F.⁶^ORCID,Yang Katharine¹^ORCID,Zhang Yuning⁷⁸,Jin Jingsi²,Liong Ka Hang¹^ORCID,Wu Dandan⁹,He Rui²,Liu Dehua¹^ORCID,Teh Ye Chean¹^ORCID,Bleriot Camille¹⁰¹¹^ORCID,Caronni Nicoletta¹²^ORCID,Liu Zhaoyuan⁹^ORCID,Duan Kaibo¹,Narang Vipin¹,Ballesteros Iván³^ORCID,Moalli Federica¹³¹⁴,Li Mengwei¹,Chen Jinmiao¹^ORCID,Liu Yao¹⁵^ORCID,Liu Lianxin¹⁵^ORCID,Qi Jingjing¹⁶¹⁷^ORCID,Liu Yingbin¹⁶¹⁷,Jiang Lingxi¹⁸¹⁹²⁰^ORCID,Shen Baiyong¹⁸¹⁹²⁰^ORCID,Cheng Hui²¹^ORCID,Cheng Tao²¹^ORCID,Angeli Veronique⁷⁸^ORCID,Sharma Ankur²²²³²⁴^ORCID,Loh Yuin-han²⁵^ORCID,Tey Hong Liang⁵²⁶²⁷^ORCID,Chong Shu Zhen¹²⁸^ORCID,Iannacone Matteo¹³¹⁴²⁹^ORCID,Ostuni Renato¹²²⁹^ORCID,Hidalgo Andrés³⁴^ORCID,Ginhoux Florent¹⁹¹⁰³⁰^ORCID,Ng Lai Guan¹²²⁸^ORCID

Affiliation:

1. Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.

2. Shanghai Immune Therapy Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

3. Area of Cell & Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.

4. Vascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

5. National Skin Centre, National Healthcare Group, Singapore.

6. Department of Mathematics & MOLAB-Mathematical Oncology Laboratory, University of Castilla-La Mancha, Ciudad Real, Spain.

7. Immunology Translational Research Program, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

8. Immunology Program, Life Science Institute, National University of Singapore, Singapore.

9. Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

10. INSERM U1015, Institut Gustave Roussy, Villejuif, France.

11. CNRS UMR8253, Institut Necker des Enfants Malades, Paris, France.

12. Genomics of the Innate Immune System Unit, San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy.

13. Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.

14. Experimental Imaging Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.

15. Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui, China.

16. Department of Biliary and Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

17. Shanghai Institute of Cancer Biology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

18. Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

19. Research Institute of Pancreatic Diseases, Shanghai Key Laboratory of Translational Research for Pancreatic Neoplasms, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

20. State Key Laboratory of Oncogenes and Related Genes, Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, China.

21. State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

22. Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands, Western Australia, Australia.

23. Curtin Medical School, Curtin University, Bentley, Western Australia, Australia.

24. Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia.

25. Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore.

26. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

27. Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

28. Department of Microbiology and Immunology, National University of Singapore, Singapore.

29. Vita-Salute San Raffaele University, Milan, Italy.

30. Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore.

Abstract

Neutrophils are increasingly recognized as key players in the tumor immune response and are associated with poor clinical outcomes. Despite recent advances characterizing the diversity of neutrophil states in cancer, common trajectories and mechanisms governing the ontogeny and relationship between these neutrophil states remain undefined. Here, we demonstrate that immature and mature neutrophils that enter tumors undergo irreversible epigenetic, transcriptional, and proteomic modifications to converge into a distinct, terminally differentiated dcTRAIL-R1 + state. Reprogrammed dcTRAIL-R1 + neutrophils predominantly localize to a glycolytic and hypoxic niche at the tumor core and exert pro-angiogenic function that favors tumor growth. We found similar trajectories in neutrophils across multiple tumor types and in humans, suggesting that targeting this program may provide a means of enhancing certain cancer immunotherapies.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/science.adf6493

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