Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells-Reference-Cited by-同舟云学术

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

Published:2015-09-04 Issue:6252 Volume:349 Page:1106-1110
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Schuijs Martijn J.¹²,Willart Monique A.¹²,Vergote Karl¹²,Gras Delphine³,Deswarte Kim¹²,Ege Markus J.⁴,Madeira Filipe Branco¹²,Beyaert Rudi⁵⁶,van Loo Geert⁵⁶,Bracher Franz⁷,von Mutius Erika⁴,Chanez Pascal³,Lambrecht Bart N.¹²⁸,Hammad Hamida¹²

Affiliation:

1. Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent, Belgium.

2. Department of Internal Medicine, Ghent University, Ghent, Belgium.

3. Department of Respiratory Medicine, Assistance Publique Hopitaux de Marseille, UMR INSERM U1067 CNRS 7333, Aix Marseille University, Marseille, France.

4. Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-Universität, Munich, Germany.

5. Unit of Molecular Signal Transduction, VIB Inflammation Research Center, Ghent, Belgium.

6. Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

7. Center for Drug Research, Department of Pharmacy, Ludwig Maximilians University, Butenandtstrasse 5-13, D-81377 Munich, Germany.

8. Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, Netherlands.

Abstract

How farming protects against allergies People who grow up on dairy farms only rarely develop asthma or allergies. This is probably because as children, they breathe air containing bacterial components, which reduce the overall reactivity of the immune system. Schuijs et al. chronically exposed mice to bacterial endotoxin before they received an allergic stimulus. The protocol indeed protected them from developing an allergic response. Protection relied on a particular enzyme: A20. In humans, a variant of A20 correlates with increased susceptibility to asthma and allergy in children growing up on farms. Science , this issue p. 1106

Funder

European Research Council

European Union FP7

Flanders Organization for Scientific Research

European Union Innovative Medicines Initiative

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference33 articles.

1. The immunology of asthma

2. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells