Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

Author:

Schuijs Martijn J.12,Willart Monique A.12,Vergote Karl12,Gras Delphine3,Deswarte Kim12,Ege Markus J.4,Madeira Filipe Branco12,Beyaert Rudi56,van Loo Geert56,Bracher Franz7,von Mutius Erika4,Chanez Pascal3,Lambrecht Bart N.128,Hammad Hamida12

Affiliation:

1. Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent, Belgium.

2. Department of Internal Medicine, Ghent University, Ghent, Belgium.

3. Department of Respiratory Medicine, Assistance Publique Hopitaux de Marseille, UMR INSERM U1067 CNRS 7333, Aix Marseille University, Marseille, France.

4. Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-Universität, Munich, Germany.

5. Unit of Molecular Signal Transduction, VIB Inflammation Research Center, Ghent, Belgium.

6. Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

7. Center for Drug Research, Department of Pharmacy, Ludwig Maximilians University, Butenandtstrasse 5-13, D-81377 Munich, Germany.

8. Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, Netherlands.

Abstract

How farming protects against allergies People who grow up on dairy farms only rarely develop asthma or allergies. This is probably because as children, they breathe air containing bacterial components, which reduce the overall reactivity of the immune system. Schuijs et al. chronically exposed mice to bacterial endotoxin before they received an allergic stimulus. The protocol indeed protected them from developing an allergic response. Protection relied on a particular enzyme: A20. In humans, a variant of A20 correlates with increased susceptibility to asthma and allergy in children growing up on farms. Science , this issue p. 1106

Funder

European Research Council

European Union FP7

Flanders Organization for Scientific Research

European Union Innovative Medicines Initiative

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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