Coupling of the TCR to Integrin Activation by SLAP-130/Fyb-Reference-Cited by-同舟云学术

Coupling of the TCR to Integrin Activation by SLAP-130/Fyb

Published:2001-09-21 Issue:5538 Volume:293 Page:2263-2265
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Peterson Erik J.¹²,Woods Melody L.³,Dmowski Sally A.¹,Derimanov Geo¹²,Jordan Martha S.¹,Wu Jennifer N.¹,Myung Peggy S.¹,Liu Qing-Hua⁴,Pribila Jonathan T.³,Freedman Bruce D.⁴,Shimizu Yoji³,Koretzky Gary A.¹⁵

Affiliation:

1. The Abramson Family Cancer Research Institute, Departments of

2. Medicine and

3. Department of Pathology and Laboratory Medicine, Center for Immunology, Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

4. Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

5. Pathology and Laboratory Medicine, School of Medicine, and the

Abstract

SLAP-130/Fyb (SLP-76–associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific adapter, which associates with and modulates function of SH2-containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76). T cells from mice lacking SLAP-130/Fyb show markedly impaired proliferation following CD3 engagement. In addition, the T cell receptor (TCR) in SLAP-130/Fyb mutant cells fails to enhance integrin-dependent adhesion. Although TCR-induced actin polymerization is normal, TCR-stimulated clustering of the integrin LFA-1 is defective in SLAP-130/Fyb–deficient cells. These data indicate that SLAP-130/Fyb is important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function, and for T cells to respond fully to activating signals.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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