Thyroid hormone signaling specifies cone subtypes in human retinal organoids-Reference-Cited by-同舟云学术

Thyroid hormone signaling specifies cone subtypes in human retinal organoids

Published:2018-10-12 Issue:6411 Volume:362 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Eldred Kiara C.¹^ORCID,Hadyniak Sarah E.¹^ORCID,Hussey Katarzyna A.¹^ORCID,Brenerman Boris¹^ORCID,Zhang Ping-Wu²,Chamling Xitiz²,Sluch Valentin M.²^ORCID,Welsbie Derek S.³,Hattar Samer⁴,Taylor James¹⁵^ORCID,Wahlin Karl³^ORCID,Zack Donald J.²⁶⁷⁸^ORCID,Johnston Robert J.¹^ORCID

Affiliation:

1. Department of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.

2. Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

3. Shiley Eye Institute, University of California, San Diego, La Jolla, CA 92093, USA.

4. National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

5. Department of Computer Science, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.

6. Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

7. Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

8. Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Abstract

Thyroid hormone in color vision development Cone photoreceptors in the eye enable color vision, responding to different wavelengths of light according to what opsin pigments they express. Eldred et al. studied organoids that recapitulate the development of the human retina and found that differentiation of cone cells into their tuned subtypes was regulated by thyroid hormone. Cones expressing short-wavelength (S) opsin developed first, and cones expressing long- and medium-wavelength (L/M) opsin developed later. The switch toward development of L/M cones depended on thyroid hormone signaling through the nuclear thyroid hormone receptor. Science , this issue p. eaau6348

Funder

Pew Charitable Trusts

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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