Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling-Reference-Cited by-同舟云学术

Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling

Published:2017-10-20 Issue:6361 Volume:358 Page:377-381
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

de Araujo Mariana E. G.¹^ORCID,Naschberger Andreas²^ORCID,Fürnrohr Barbara G.²^ORCID,Stasyk Taras¹^ORCID,Dunzendorfer-Matt Theresia²^ORCID,Lechner Stefan²^ORCID,Welti Stefan²^ORCID,Kremser Leopold³,Shivalingaiah Giridhar²^ORCID,Offterdinger Martin⁴,Lindner Herbert H.³^ORCID,Huber Lukas A.¹⁵^ORCID,Scheffzek Klaus²^ORCID

Affiliation:

1. Division of Cell Biology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria.

2. Division of Biological Chemistry, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria.

3. Division of Clinical Biochemistry, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria.

4. Division of Neurobiochemistry-Biooptics, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria.

5. Austrian Drug Screening Institute, 6020 Innsbruck, Austria.

Abstract

Structure of human mTORC1 components The mTORC1 (mechanistic target of rapamycin complex 1) complex garners much attention as a signaling hub that coordinates input from growth-factor receptors and nutrient availability with metabolism and cell growth and proliferation. de Araujo et al. report the crystal structure of the LAMTOR (or “Ragulator”) complex that helps assemble mTORC1 at the lysosomal membrane for activation. The structure and functional studies reveal how LAMTOR1 wraps around the other subunits to hold them in place and interacts with the Rag guanosine triphosphatases in the complex. Science , this issue p. 377

Funder

Austrian Science Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference60 articles.

1. Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

2. Localization of the MP1-MAPK Scaffold Complex to Endosomes Is Mediated by p14 and Required for Signal Transduction

3. Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

4. Regulation of mTORC1 by amino acids

5. The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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