The Role of Locus Coeruleus in the Regulation of Cognitive Performance-Reference-Cited by-同舟云学术

The Role of Locus Coeruleus in the Regulation of Cognitive Performance

Published:1999-01-22 Issue:5401 Volume:283 Page:549-554
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Usher Marius¹,Cohen Jonathan D.¹,Servan-Schreiber David¹,Rajkowski Janusz¹,Aston-Jones Gary¹

Affiliation:

1. M. Usher, Department of Psychology, University of Kent, Canterbury, UK. J. D. Cohen, Department of Psychology, Princeton University, Princeton, NJ 08540, USA and Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA. D. Servan-Schreiber, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA. J. Rajkowski and G. Aston-Jones, Department of Psychiatry, University of Pennsylvania, VAMC (151), University and Woodland Avenues, Philadelphia, PA 19104, USA.

Abstract

Noradrenergic locus coeruleus (LC) neurons were recorded in monkeys performing a visual discrimination task, and a computational model was developed addressing the role of the LC brain system in cognitive performance. Changes in spontaneous and stimulus-induced patterns of LC activity correlated closely with fluctuations in behavioral performance. The model explains these fluctuations in terms of changes in electrotonic coupling among LC neurons and predicts improved performance during epochs of high coupling and synchronized LC firing. Cross correlations of simultaneously recorded LC neurons confirmed this prediction, indicating that electrotonic coupling in LC may play an important role in attentional modulation and the regulation of goal-directed versus exploratory behaviors.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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4. Training and experimental recording sessions took place in an acoustically insulated electrically shielded metal chamber (IAC Bronx NY). Monkeys were trained to depress a lever and to stably foveate a fixation stimulus on a video monitor at which point this stimulus was replaced by a target or nontarget stimulus (horizontally or vertically oriented rectangle). The animal was required to selectively release the lever in response to the target stimulus (20% of trials). Responses to the other stimulus were not reinforced but instead generated a 3-s time-out. Training continued until animals performed at a level of at least 85% correct. See (2) for more details.

5. Typically epochs of poor performance contained more than seven times the frequency of FA errors as epochs of good performance. The hit rates varied only slightly between these periods remaining either constant or declining slightly during poor performance intervals. For the three monkeys analyzed the d ′ values in poor compared with good periods increased from 2.9 to 5.1 3.7 to 4.7 and 3.7 to 5.1. The response criterion b also increased during the good periods from 0.23 to 0.82 0.36 to 2.92 and 0.06 to 1.11 respectively. For these monkeys the standard deviations of RTs were 58 55 and 46 ms respectively during poor intervals and 35 33 and 35 ms respectively during epochs of good performance ( P < 0.001; Levene test of variances).

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