Comment on "Ongoing Adaptive Evolution of ASPM , a Brain Size Determinant in Homo sapiens " and " Microcephalin , a Gene Regulating Brain Size, Continues to Evolve Adaptively in Humans"-Reference-Cited by-同舟云学术

Comment on "Ongoing Adaptive Evolution of ASPM , a Brain Size Determinant in Homo sapiens " and " Microcephalin , a Gene Regulating Brain Size, Continues to Evolve Adaptively in Humans"

Published:2006-07-14 Issue:5784 Volume:313 Page:172-172
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Currat Mathias¹²,Excoffier Laurent¹²,Maddison Wayne¹²,Otto Sarah P.¹²,Ray Nicolas¹²,Whitlock Michael C.¹²,Yeaman Sam¹²

Affiliation:

1. Department of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

2. Computational and Molecular Population Genetics (CMPG), Zoological Institute, University of Bern, 6 Baltzerstrasse, CH-3012 Bern, Switzerland.

Abstract

Mekel-Bobrov et al . and Evans et al . (Reports, 9 Sept. 2005, p. 1720 and p. 1717, respectively) examined sequence data from modern humans within two gene regions associated with brain development, ASPM and microcephalin , and concluded that selection of these genes must be ongoing. We show that models of human history that include both population growth and spatial structure can generate the observed patterns without selection.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference8 articles.

1. Ongoing Adaptive Evolution of ASPM , a Brain Size Determinant in Homo sapiens

2. Microcephalin , a Gene Regulating Brain Size, Continues to Evolve Adaptively in Humans

3. Mutations arising in the wave front of an expanding population

4. The Fate of Mutations Surfing on the Wave of a Range Expansion

5. Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa

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