RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence-Reference-Cited by-同舟云学术

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence

Published:2016-04-22 Issue:6284 Volume:352 Page:453-459
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Galloway Alison¹,Saveliev Alexander¹,Łukasiak Sebastian¹,Hodson Daniel J.¹²,Bolland Daniel³,Balmanno Kathryn⁴,Ahlfors Helena¹,Monzón-Casanova Elisa¹⁵,Mannurita Sara Ciullini¹,Bell Lewis S.¹,Andrews Simon⁶,Díaz-Muñoz Manuel D.¹,Cook Simon J.⁴,Corcoran Anne³,Turner Martin¹

Affiliation:

1. Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge CB22 3AT, UK.

2. Department of Haematology, University of Cambridge, The Clifford Allbutt Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0AH, UK.

3. Laboratory of Nuclear Dynamics, The Babraham Institute, Cambridge CB22 3AT, UK.

4. Laboratory of Signalling, The Babraham Institute, Cambridge CB22 3AT, UK.

5. Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.

6. Bioinformatics Group, The Babraham Institute, Cambridge CB22 3AT, UK.

Abstract

Reducing the risk of rearrangement As lymphocytes develop, they rearrange their antigen receptor genes and proliferate extensively, potentially putting their genomes at risk. Galloway et al. found that two RNA-binding proteins, ZFP36L1 and ZFP36L2, ensure careful entry and exit into the cell cycle. This helps developing B lymphocytes maintain their genomic integrity. Mice deficient in ZFP36L1 and ZFP36L2 exhibited a profound block in B cell development. ZFP36L1 and ZFP36L2 suppress mRNAs that help B cells progress through the cell cycle, ensuring that cells can enter quiescence and keep their genomes safe when they undergo the risky process of rearranging their antigen receptors. Science , this issue p. 453

Funder

Biotechnology and Biological Sciences Research Council

Medical Research Council (MRC)

Collaborative Award in Science and Engineering (CASE)

GlaxoSmithKline

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference50 articles.

1. IL-7 Functionally Segregates the Pro-B Cell Stage by Regulating Transcription of Recombination Mediators across Cell Cycle

2. Single-Cell Trajectory Detection Uncovers Progression and Regulatory Coordination in Human B Cell Development